ABSTRACT: Melt   in   mouth   tablets   are   oral   solid   dosage   form   which   when   placed   on   tongue   disintegrates   rapidly,   releasing   the   drug,   which   dissolves or   disperses   in   the   saliva   and   then   swallowed   with   or   without   heat   of   saliva.   Melt   in   Mouth   tablets   provide   an   advantage   particularly   for pediatric   and   geriatric   populations   who   have   difficulty   in   swallowing   conventional   tablets   and   capsules.   It   is   very   important   drug   delivery system   in   case   where   drug   absorbed   from   buccal   cavity.   Rapid   disintegration   of   tablet   cause   quick   dissolution   and   thus   fast   onset   of action.    It   provides   good   stability,   accurate   dosing,   easy   manufacturing,   reduced   packaging   size;   self   administration   is   possible   during travelling   as   water   is   not   required   and   easy   to   handle   by   patients .   It   is    easy   to   administer   for   pediatric,   geriatric,   and   institutionalized patients especially for uncooperative patients. KEYWORDS:   Melt in Mouth, Rapid Melt, Mouth Dissolving, Oro Dispersible, buccal cavity.

ABSTRACT: Intelligent   drug-delivery   systems   are   described   as   novel   technological   innovations   and   clinical   approaches   to   improve   conventional treatments.   These   systems   differ   in   methodology   of   therapeutic   administration,   intricacy,   materials   and   patient   compliance   to   address numerous   clinical   conditions   that   require   various   pharmacological   therapies.   Drug   delivery   systems   (DDS)   capable   of   releasing   an active   molecule   at   the   appropriate   site   and   at   a   rate   that   adjusts   in   response   to   the   progression   of   the   disease   or   to   certain functions/biorhythms   of   the   organism   are   particularly   appealing.   Biocompatible   materials   sensitive   to   certain   physiological   variables   or external   physicochemical   stimuli   (intelligent   materials)   can   be   used   for   achieving   this   aim.    This   new   class   of   intelligent   drug   delivery includes   pulsatile   drug   delivery,   responsive   delivery   systems,   systems   utilizing   enzymes   and   antibodies   that   are   designed   to   perform various   functions   like   detection,   isolation   and/or   release   of   therapeutic   agent   for   the   treatment   of   diseased   conditions.   In   pulsatile   drug delivery   system   drug   release   is   programmed   by   external   stimuli   like   magnetism,   ultrasound,   electrical   effect   and   irradiation   etc.    The most   critical   considerations   for   the   design   of   these   intelligent   delivery   systems   include   the   controlled   release,   target   specificity,   on- demand    dosage    adjustment,    mass    transfer    and    stability    of    the    pharmacological    agents.    Drug-delivery    systems    continue    to    be developed   and   enhanced   to   provide   better   and   more   sophisticated   treatments,   promising   an   improvement   in   quality   of   life   and extension of life expectancy.   KEYWORDS: Intelligent drug delivery system, Biocompatible materials , In situ gel, Responsive systems, Microchips.

ABSTRACT: In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (monolithic or bilayer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation, and to enable the development of different drug release profiles (immediate release with sustained release). Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield etc. Using a modified tablet press may therefore not be best approach in producing a quality bi-layer tablet under GMP conditions, especially when high production output is required. There are various applications of the bi-layer tablet consists of monolithic partially coated or multilayered matrices. KEY WORDS: Bilayer tablets ,   modified tablet press , Bilayer tablet press