Psyllium Husk: Potential Natural polymer for floating Drug DeliveryPatel N. Thakkar A
ABSTRACT:Melt in mouth tablets are oral solid dosage form which when placed on tongue disintegrates rapidly, releasing the drug, which dissolves or disperses in the saliva and then swallowed with or without heat of saliva. Melt in Mouth tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. It is very important drug delivery system in case where drug absorbed from buccal cavity. Rapid disintegration of tablet cause quick dissolution and thus fast onset of action.It provides good stability, accurate dosing, easy manufacturing, reduced packaging size; self administration is possible during travelling as water is not required and easy to handle by patients. It is easy to administer forpediatric, geriatric, and institutionalized patients especially for uncooperative patients.KEYWORDS:Melt in Mouth, Rapid Melt, Mouth Dissolving, Oro Dispersible, buccal cavity.
ABSTRACT:Intelligent drug-delivery systems are described as novel technological innovations and clinical approaches to improve conventional treatments. These systems differ in methodology of therapeutic administration, intricacy, materials and patient compliance to address numerous clinical conditions that require various pharmacological therapies. Drug delivery systems (DDS) capable of releasing an active molecule at the appropriate site and at a rate that adjusts in response to the progression of the disease or to certain functions/biorhythms of the organism are particularly appealing. Biocompatible materials sensitive to certain physiological variables or external physicochemical stimuli (intelligent materials) can be used for achieving this aim. This new class of intelligent drug deliveryincludes pulsatile drug delivery, responsive delivery systems, systems utilizing enzymes and antibodies that are designed to perform various functions like detection, isolation and/or release of therapeutic agent for the treatment of diseased conditions. In pulsatile drug delivery system drug release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation etc. Themost critical considerations for the design of these intelligent delivery systems include the controlled release, target specificity, on- demand dosage adjustment, mass transfer and stability of the pharmacological agents. Drug-delivery systems continue to be developed and enhanced to provide better and more sophisticated treatments, promising an improvement in quality of life and extension of life expectancy.KEYWORDS: Intelligent drug delivery system, Biocompatible materials , In situ gel, Responsive systems, Microchips.
ABSTRACT:In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (monolithic or bilayer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation, and to enable the development of different drug release profiles (immediate release with sustained release). Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield etc. Using a modified tablet press may therefore not be best approach in producing a quality bi-layer tablet under GMP conditions, especially when high production output is required. There are various applications of the bi-layer tablet consists of monolithic partially coated or multilayered matrices.KEY WORDS:Bilayer tablets,modified tablet press, Bilayer tablet press
ABSTRACT:This work approached with to formulate directly compressible fast disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of concentration of superdisintegrant, Ac-di-sol and directly compressible material, tablettose® 70 on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro disintegrating time, wetting time and in vitro drug release. A 32 full factorial design was applied to investigate the combine effect of 2 formulation variable: directly compressible material, tablettose® 70 andSuperdisintegrant, Ac-di-sol. Here the concentration of directly compressible material and concentration of superdisintegrant were taken as independent variable, X1 and X2 respectively. The effect of Disintegration time, wetting time, Q15 and friability were investigated as dependent parameters. The results of analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of superdisintegrant and a higher percentage of directly compressible material. The systematic formulation approach helped in understanding the effect of formulation processing variables.Key words: fast disintegrating tablet, Cinnarizine, 32 factorial design, tablettose® 70, Ac-di-sol