jan_feb_2014

ABSTRACT: Pain is the most troublesome event encountered in many diseases and states of injury. Conventional analgesics are useful but have serious draw-backs in terms of their side effects and toxicities hence the search of herbal remedies capable of counteracting pain is going on simultaneously. Traditionally Acacia sinuata is reported to possess analgesic activity but literature survey shows that this activity has not been yet evaluated. Hence Acacia sinuata was chosen for evaluation of its possible analgesic effect. Ethanolic extract of Acacia sinuata pods (ASE) was administered orally in rats and mice at the dose of 200 mg/kg and 400 mg/kg. The tail flick test, hot plate test and acetic acid induced writhing test were used for evaluation of anti-nociceptive activity of ASE using Diclofenac sodium (25 mg/kg) as reference drug. ASE significantly increased the latency for tail flick, jumping time from hot plate and reduced number of writhes induced by acetic acid suggesting good anti-nociceptive activity. Results of the study confirmed the ethno medical use of Acacia sinuata in painful conditions. ASE acts probably by inhibiting the release, synthesis and / production of inflammatory mediators like polypeptides, kinins, prostaglandins etc. Further research in this direction would clarify its exact mechanism of action justifying its use as an effective analgesic agent. Keywords: Pain, Analgesic, Acacia sinuata, Anti-nociceptive, Diclofenac sodium

ABSTRACT: A new series of Thiazolidine-4-one showed diversified antibacterial activities. In view of potential antibacterial activities of thiazolidine-4- one derivative were prepared by schiffs base technique. The compound were screened by antibacterial activity, thiazolidine -4-one also showed antifungal activit hypoglycemic activity, anti-convulsant activity, analgesic activity, anti-tubercular activity and anti-inflammatory activity.Thiazolidine-4-one also related to ketone group, amine group, sulpher group and thiazolidine ring. Keywords: Schiffs base. Thiazolidine -4- one. Anti-bacterial activity.

ABSTRACT: Controlled and sustained drug delivery has become the standard in modern pharmaceutical design and an intensive research work is going on in obtaining better drug product effectiveness, reliability and safety. In this regard, many polymers are very useful with majority of hydrogels, which undergo reversible volume and/or sol-gel phase transitions in response to physiological or other external stimuli. The first use of gels for medical applications was presented by Wichterle and Lim in 1960 and involved the manufacturing of soft contact lenses.Poly (Acrylamide-co-acrylic acid) hydrogels,poly(AAm-co-AAc),were synthesized by free radical crosslinking copolymerization in solution using N,N’-methylenebisacrylamide (MBAAm) as the crosslinker. The swelling behaviour of the hydrogels thus obtained was analyzed in buffer solutions at various pH.The pH sensitive hydrogel were characterizedby Fourier transform infrared analysis, differential scanning calorimetry and evaluated for swelling properties,SEM, and in vitro drug release. The use of hydrogels for drug release was investigated with Rabeprazole sodium as the model drug. The release data shows that, as the concentration of acrylic acid was increased, swelling increased resulting in increased release of the drug. Keywords: Hydrogel; Poly (Acrylamide-co-acrylic acid); N, N’-methylenebisacrylamide; pH sensitive.

ABSTRACT: Liquisolid system is a novel concept of dosage formulation for water insoluble drugs and lipophilic drugs via oral route. Formulation concept of liquisolid technology involves water insoluble drugs dissolved in suitable non- volatile liquid vehicles, and converted in to compact by blending with selective powder excipients. Liquisolid compacts are compressible powdered forms of liquid medications, and they are industrially applicable. The liquisolid technology allows the transformation of liquid systems into solid drug delivery systems such as tablets. The liquisolid approach has been successfully applied in release enhancement of low dose poorly soluble drugs. However, the formulation of high dose poorly soluble drugs is one of the limitations of this technique because of the high amount of liquid vehicle needed. Consequently, high amounts of carrier and coating material are required ultimately leading to an unacceptably high tablet weight. Keywords: Liquisolids, solubility enhancement, carriers, coating materials, water in-soluble/ soluble drugs.

ABSTRACT: The objective of present study was to compare two skin closure techniques – vertical mattress sutures and subcuticular sutures in clean surgical wounds. This was a hospital based comparative study of 100 Indoor participants. Patients undergoing in different surgeries like hernia repair, appendicectomy, suprapubic cystolithotomy, wound closure, excision of swelling and thyroid surgeries were included in the study. Half of randomly chosen Participants’skin approximation was done by vertical mattress suturing by 3-0 polyamide black and half by subcuticular suturing by 3-0 polyglactin 910. The overall number of male patients was 71%. Maximum number of patients (23%) being in age groups 21-30 years. The wound complication is seen more in patients with vertical mattress sutures than with sucuticular sutures. Pus discharge is seen in vertical mattress sutures (4%).Wound dehiscence is seen in subcuticular sutures (4%).Local stitch site oedema/erythema /redness is more in patients with vertical mattress sutures as compared to subcuticular sutures. Cosmetic look of the wound and scar is better with subcuticular sutures (28%) as compared to vertical mattress sutures (10%). Subcuticular suture is technically difficult method of skin closure than vertical mattress technique but with superior cosmetic results and better patient compliance. Key words: vertical mattress sutures, subcuticular sutures, type 1 surgery

ABSTRACT: The aim of this research work is to formulate an oral controlled drug delivery system for Metoprolol tartrate. Instead of normal trial & error method, a standard experimental design was adapted to study the effect of formulation variables in the development of the oral controlled drug delivery system of Metoprolol tartrate. A CCD was adapted to study the effect of formulation variables on the release properties with amount of HPMCK100M & CAP as two independent variables. Tablets were prepared following wet granulation technique by using IPA as granulating agent. The formulated dosage forms were evaluated for both pre-compression & post- compression parameters. Further, the results of the pre compression parameters were found to be within the permissible limits of the Pharmacopoeia. The release mechanism of Metoprolol tartrate from the matrix tablets were evaluated on the basis of Korsmeyer and Peppas model which indicate the mechanism of drug release from the optimized dosage form as non fickian transport. Validation of optimization was carried out and the results obtained from optimized formula were close to the predicted values which indicate a good reproducibility. A short term stability studies were conducted as per ICH guidelines for the Optimized formula and it was found to be stable for long period of time. KEY WORDS: Controlled drug delivery systems, Cellulose Acetate Phthalate, Matrix tablet, Hydroxypropylmethylcellulose(HPMC) K100M, Central Composite Deign.

ABSTRACT: The present work deals with the formulation of buccal drug delivery system for management of hypertension containing valsartan as API. A sustained release (6 hours) buccoadhesive dosage forms, namely, unidirectional release mucoadhesive film is formulated. The in-vitro preliminary dissolution studies revealed that HPMC K4M and Methylcellulose 400cps are excellent film forming polymer and hydrophilic PVP K-30 as mucoadhesive agent based on separability, solubility in the ethanol solvent system, film forming property, flexibility and physical appearance of film. The bilayered film was designed with ethyl cellulose as backing membrane and the drug incorporated in mucoadhesive layer. A 3 ² full factorial design approach was employed to build the quality into formulation and thus showed the predictive drug release characteristics. Results of multiple regression analysis revealed that the independent variables significantly affected the dependent variables. The optimized bilayered film batch exhibited Surface pH 6.88, Swelling index 4.2 % ,Tensile strength 118g/cm2, 91.64% drug release in 6 hours, Ex vivo muco adhesion time 320 minutes and also releases the drug in unidirectional fashion towards the mucosa till 6 hours . Key words: Valsartan, 3 ² full factorial design, buccal drug delivery, Unidirectional Release