ABSTRACT:Neuropathic pain is caused by a lesion or disease of somatosensory nervous system and its treatment remains a challenge. The purpose of the present study was to evaluate efficacy of Tolperisone, a centrally acting muscle relaxant in reducing neuropathic pain and also attempt to establish its mechanism of action by comparing its effectiveness with standard drug Phenytoin. Neuropathic pain was induced in rats using Spared Nerve Injury Model (SNIM). The Successful induction of neuropathic pain was evaluated by observing hyperalgesia and allodynia in rats exposed to various stimuli. The Effectiveness of Tolperisone (10mg/kg) in treatment of Neuropathic pain was evaluated by comparing the results obtained with Standard drug Phenytoin (20mg/kg) and results indicate that voltage-gated sodium channel probably contributes to development of hyperalgesia and allodynia in the SNI model. Phenytoin which is sodium channel blocker drug exerts a potent anti-hyperalgesic and anti-allodynic. Tolperisone shows effects similar to Phenytoin and emphasizes the concept that blockade of Na+ channels may be beneficial for treatment of neuropathic pain in humans.Keywords: Spared Nerve Injury (SNI), Neuropathic pain, allodynia, hyperalgesia, somatosensory system.
ABSTRACT:The present work is aimed to develop a stable formulation of preferred combination of two antibiotics -Amoxycillin and Clavulanic acid to overcome packaging instability resulting in to swelling of blister pack due to their interaction causing gas generation. Amoxycillin and Clavulanic acid dispersible tablets were prepared by dry granulation method using different superdisintegrants i.e. Croscarmellose, Crospovidone and Sodium Starch Glycolate. 15°C temperature and 20%RH humidity were throughout maintained. Aspartame as a sweetener and pineapple flavor were used to increase palatability. The prepared tablets were evaluated for hardness, friability, Disintegration time and Wetting time and in vitro drug release. Analytical estimation was done by HPLC. Amoxycillin and Clavulanic acid dispersible tablets were found to be of good quality fulfilling all the requirements for tablets. The results indicated that concentration of Crospovidon, Croscarmellose sodium, Sodium starch glycolate significantly affected. Croscarmellose Sodium showed least friability, disintegration time as compared to batches prepared from Sodium starch glycolate and Crospovidon. Amoxycillin and Clavulanic acid dispersible tablets were successfully formulated by dry granulation technique with improved patient compliance & immediate onset of action.Key Words: Dispersible tablets, Amoxycillin and Clavulanic acid, Stability, dry granulation, Croscarmellose sodium, Disintegration time.
ABSTRACT:Gastric ulcer usually develops due to a break in the tissue lining of the stomach. Formation of gastric ulcer is a complex mechanism. Several factors are responsible for the pathogenesis of gastric ulcer. The present article provides all information regarding causal factors that help in understanding of pathogenesis of ulcer. It includes gastric acid, histamine, NSAIDs, H. pylori infection, oxidative stress and bile acids. It also includes various recent approaches for the treatment of the ulcers like- role of nitric oxide, role of copper complex, probiotics, role of growth hormones and herbal drugs like curcuminoids. KEY WORDS: - H. pylori, Apoptosis, Copper complex, Probiotics.
ABSTRACT:The aim of the present investigation is to design and development of controlled release formulation of Captopril based on osmotic technology to increase the resident time in order to improve the therapeutic effect of the drug by increasing its bioavailability. Captopril is antihypertensive drug, it is soluble in water; its maximum absorption is from the stomach and upper part of the intestine. So the aim to make the Oral Osmotic tablets to get maximum absorption throughout the GI Tract. A present investigation comprises a drug Captopril, Sodium Lauryl Sulphate, Tromethamine , Mannitol, Lactose, Povidone K30. The prepared tablets were subjected to post- compression parameters such as hardness, friability, weight variation, thickness, drug content, lag time subsequently buoyancy time, and in-vitro dissolution studies. Drug compatibility with excipients was checked by FTIR and DSC studies. The formulations F04C2 was found to be promising, which shows an in vitro drug release of 98.32% in 24 hrs. All the formulations exhibited diffusion dominated drug release.Keywords: Captopril, Osmotic tablets, Controlled release