Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Cefuroxime Axetil
and Linezolid in Tablet Dosage Form
Rima N. Chavda, Hitendra N. Yadav , Madhuri A. Hinge , Shuchi P. Desai
A Review on Multiple Compressed Tablets
H. P. Patel, D. M. Jariwala, , C. T. Desai, S. A. Shah and D. R. Shah
Volume 6, Issue 3, Pages no. 365-460 , ISSN 2277-3681
Available online on 1 May 2016
J Pharm Sci Bioscientific Res. 2016; 6(3):365- 460
Biological review of Ni(II) Complexes Based on Enrofloxacin and Dicumarol derivative
Charulataben L Patel, Rajesh R Paramar, Kiran S Nimavat and Kartik B Vyas
Special Chalcones and their novel Antimicrobial Activities
Arpita Desai, K.B. Vyas, Rajarshi N. Patel and K.S.Nimavat
Study Self-Association of Norfloxacin and Ciprofloxacin, and their Thermodynamic Properties
Ataklti Abraha.
Development and Validation of Stability Indicating RP-HPLC Method for Simultaneous Estimationof Ilaprazole and
Domperidone in their Combined Tablet Dosage Form
Pinky Jain, Mandev B. Patel
Gellified Emulsion: A Review of State of Art and Recent Advances
Munjal Mehta, Nihar Shah, Shreeraj Shah
Copyright © 2014 JPSBR Publications
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Potential Review for the Treatment of psoriasis
Abhishek patel, Nihar Shah, Shreeraj Shah
Potential Review of Hydrilla
Vashisth P Bhavsar, Asshish H Panchal, Omprakash Maheshwari
Haematological and Serological Responses of Clarias Gariepinus to Sublethal Concentrations of Lead Nitrate
Igwilo Innocent, Nsofor C.I., Ngene A.A.
Formulation and Optimization of Ciprofloxacin Ocular Liposomal Hydrogel
Abhishek patel, Nihar Shah, Shreeraj Shah
Formulation, Optimization and Evaluation of Extended Release Tablet of Pregabalin for the Treatment of Diabetic Neuropathy
Karishma Halatwala, Nayan Ratnakar, Tushar Patel, Dhaval Madat
Formulation Development and Evaluation of Sustained Release Matrix Pellets of Tizanidine Hydrochloride
Jignesh Pandwala, Dhaval Madat, Tushar Patel,Nayan Ratnakar
Gastroretentive Microballoons of Propafenone HCl : Formulation, Development and its In-Vitro Evaluation
Prachi Jogi, Tushar Patel, Dhaval Madat, Nayan Ratnakar
Tharmal and Biological Estimate and Characterization of Cu(II) Complexes Based on Getifloxacin
V.R.Chaudhari, K.B.Vyas , K.S.Nimavat , K. S. Patel
Synthesis of 6-Phenyl pyrimidine Amine Derivatives Based Chalcones and their Antibacterial Activity
Sandeep Mekde, K.S.Nimavat and K.B. Vyas
Synthesis of Novel Chalcones and their Antibacterial Activity
Sandeep Mekde, K.S.Nimavat, R. A. Shah, K.B. Vyas
A Survey on Knowledge, Practice and Perception of Physicians and Pharmacists on Adverse Drug Reaction
Reporting- A Pilot Study
Jainam Shah, Jolly M. Patel, Kalyani N. Patni, Sneha Chacko
ABSTRACT:
To develop simple, sensitive, accurate, rapid and precise first derivative spectrophotometric method for the simulataneous estimation of
Cefuroxime Axetil (CEF) and Linezolid (LIN) in Tablet dosage form. The derivative spectrophotometric method was based on the
determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectrum was obtained in
methanol and the determinations were made at 257.40 nm (ZCP of Linezolid) for Cefuroxime Axetil and 276.60 nm (ZCP of Cefuroxime
Axetil) for Linezolid. The linearity was obtained in the concentration range 2-6 ìg/ml for Cefuroxime Axetil and 2.4-7.2 ìg/ml for Linezolid.
The results of analysis have been validated statistically and by recovery studies.
KEY WORDS: Cefuroxime Axetil (CEF), Linezolid (LIN), First Order Derivative Method.
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ABSTRACT:
Multiple compressed tablets are compressed tablets made by more than one compression cycle. They are usually prepared to separate
physically or chemically incompatible ingredients or to produce repeat or prolong action of drug. Compression coating perform similar
functions as sugar or film coating except consists of dry coating concept hence prevents certain drawbacks of aqueous and non aqueous
solvents used in sugar and film coating. There are three categories under this class: Compression coated tablets, Inlay tablets and Layered
tablets. Multiple compression tablets, especially layered tablets, tend to solve incompatibility issues between two or more active
pharmaceutical ingredients (APIs). Bilayer tablet provides adequate surface separation of two reactive ingredients but there may be some
reactivity at the interface. If complete physical separation is required for stability purposes then three layered tablet may be employed.
KEYWORDS: dry coating, layered tablet, Inlay tablet, Incompatibilities.
ABSTRACT:
Some newly heterochelates synthesized by reflux of different coumarin derivative, Enrofloxacin and transition metal. The
structures of the ligands and their copper complexes were investigated and confirmed by the elemental analysis, FT-IR, 1H-
NMR, 13C-NMR, and mass spectral data. Thermal behavior of newly synthesized mixed ligand Ni(II) complexes were
investigated by means of thermogravimetry, electronic spectra and magnetic measurements. The compounds were screened
for their antimicrobial and antioxidant viewing using serial broth dilution method and Minimum Inhibitory Concentration (MIC)
is determined.
KEY WORDS: Enrofloxacine, biological study, Octahedral complexe.
ABSTRACT:
Some newly heterochelates synthesized by reflux of different Coumarin derivative, Getifloxacin and transition
metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The heterochelates were characterized on the
basis of different spectroscopic techniques like IR studies and elemental analysis while the geometry of
complexes was octahedral which is confirmed by electronic spectra. The compounds were subjected to
antimicrobial, antioxidant and anti-tubercular activity viewing using serial broth dilution method and Minimum
Inhibitory Concentration (MIC) is determined.
Key words: Getifloxacin, biological facet, Coumarin derivative
ABSTRACT:
4-(4-chlorophenoxy)-1,2-dimethylbenzene react with 1-(4-hydroxyphenyl)ethanone in presence of copper metal
as a catalyst gives 1-(4-(4-(3,4-dimethylphenoxy) -phenoxy)phenyl)ethanone,this derivatives react with various
substituted aldehyde to give corresponding substituted chalcone derivatives. Now these derivatives on
condensation with Guanidine nitrate give the vast range of phenyl pyrimidine amine Derivatives. Structure
elucidation of synthesized compound had been made on the basis of element analysis, 1H NMR Spectra
studies. The microbial activity of the synthesized compounds has been studied against the species bacillus
subtillis, staphylococcus aureus, Escherichia coli, and salmonella typhi.
KEY WORDS: Synthesis, heterocyclic substituted chalcone derivatives, Pyrimidine derivatives, Chalcon
ABSTRACT:
Chalcones have been the center of attraction for researchers from several decades due to nits innumerous therapeutic
application, Efforts have been done in my research to synthesized chalcones and their derivatives that further reacts with various
substituted aldehyde to give corresponding substituted chalcone derivatives .Now these derivatives on condensation with
Guanidine nitrate gives the vast range of phenyl pyrimidine amine Derivatives. Structure elucidation of synthesized compound
had been made on the basis of element analysis, 1H NMR Spectra studies. The microbial activity of the synthesized compounds
has been studied against the species bacillus subtillis, staphylococcus aureus, Escherichia coli, and salmonella typhi.
Key words: Synthesis, heterocyclic substituted chalcone derivatives, Pyrimidine derivatives, Chalcones
ABSTRACT:
A simple, rapid, precise and accurate reversed-phase stability-indicating RP-HPLC method was developed and validated for
the UV/Vis spectroscopy has been used to investigate the self-association of the Quinolone drugs (Norfloxacin and
Ciprofloxacin) in aqueous solution at room temperature (295) K. The calculated value for the dimerization constant of
these drugs self-association analyzed using dimer model equation by fitting to the experimental value are
3 1 5.424 10 ƒ{ „e M and 3 1 4.377 10 ƒ{ „e M respectively. The thermodynamic parameters (Gibbs free energy, enthalpy
and entropy) of dimerization reactions for the self-association of the drugs were also investigated using Vant¡¦s Hoff
equation at the temperature ranges (295-304 K). The change of enthalpy calculated for Norfloxacin and Ciprofloxacin
are ƒ{ (5.35 „b 0.459) and ƒ{ (1.98 „b 0.25)
1 . ƒ{ kJ mol respectively. The values of change in enthalpy and entropy indicate
that the electrostatic forces play the major role in the interaction between the molecules of the drugs. Finally the
results of the study are useful in order to design the advanced and controllable carriers of drug components and for
controlling the effect of physicochemical properties (such as the degree of ionization, reaction rates and reaction
mechanisms) of the drugs.
Key words: Norfloxacin, Ciprofloxacin, UV-Vis Spectroscopy, Self-association, Thermodynamic property
ABSTRACT:
A simple, rapid, economical, precise and accurate stability indicating RP-HPLC method for simultaneous estimation of Ilaprazole
and Domperidome in their combined dosage forms has been developed. A reverse phase high performance liquid
chromatographic method was developed for the simultaneous estimation of Ilaprazole and Domperidon in their combined dosage
form has been developed. The separation was achieved by C18 (25cm x .46 cm ) column and water: Acetonitrle: Acetic acid
(30:70:0.1) as mobile phase, at a flow rate of 1ml/min. Detection was carried out at 255 nm retention time of Ilaprazole and
Domperidone were found to be 4.640 min and 7.633 min, respectively. The method has been validated for linearity, accuracy and
precision. Linearity observed for Ilaprazole 5-15 ug/ml and for Domperidone 15-45 ug/ml. The percentage recoveries obtained for
Ilaprazole and Domperidone were found to be in range of 100.36-100.83% and 100.90-101.45%, respectively. Developed method
was found to be accurate, precise and rapid for simultaneous estimation of Ilaprazole and Domperidone in their combined dosage
form. The drug was subjected to stress condition of hydrolysis, oxidation, photolysis and Thermal degradation, Considerable
Degradation was found in alkaline degradation. The proposed method was successfully applied for the simultaneous estimation of
both the drugs in commercial combined dosage form.
Key words: Ilaprazole, Domperidone, stability indicating RP-HPLC method, validation,
ABSTRACT:
Gellified emulsion is the emergent dosage form in the topical dosage form which deals with the combination of emulsion and
gelling agent. The presence of dual control release system makes it suitable for the topical drug delivery system. gellified
emulsion is mainly used to formulate the hydrophobic drugs topically. The efforts given are in the direction of skin disorders and
cosmetology. It is beneficial compare to the other dosage form in the terms of drug release as well as it is non greasy, and high
patient compliance is obtained. The present review deals with the various factors to be selected while formulating gellified
emulsion as well as different methods associated with the formulation. After extensive review we can say that the gellified
emulsion is better in terms of drug release, Rheological property and aesthetic appearance compare to the other dosage forms.
KEY WORDS: Topical drug delivery, Emulgel, Gellified emulsion, Advances
ABSTRACT:
Psoriasis is a common, chronic, relapsing, papulo-squamous dermatitis, with overlying silvery scales. Psoriasis is an autoimmune disease.
Genetic and environmental factors play a important role in psoriasis. The most commonly affected sites are the scalp, elbows, knees,
umbilicus, genitalia, sacrum and shins. Psoriasis affects 3% of the population of the world. First-line treatments are topical: emollients,
dithranol, tar, deltanoids and corticosteroids. Second-line treatments have more side effects and include phototherapy and systemic drugs:
methotrexate, cyclosporine, acitretin, hydroxycarbamide and fumarates. Biological therapies are costly and demonstrate
immunosuppressant activity, and are currently reserved for patients unable to benefit from first-line and second-line modalities. We aim to
briefly describe the biology of psoriasis, document the key features of treatments that are available or under development, and explain how
these treatments can be used effectively to manage this chronic relapsing disease.
KEY WORDS: Psoriasis, Treatment, Autoimmune disease. Relapsing
ABSTRACT:
Hydrilla verticillata (L.f.) Royle (Hydrocharitaceae) is a submerged aquatic angiosperm that is thought to be native in various tropical and
subtropical areas such as the warmer regions of Asia, Australia, and United States which become established in a variety of fresh water
habitats around the world. Where the plant occurs, it causes substantial economic hardships, interferes with various water uses,
displaces native aquatic plant communities, and adversely impacts freshwater habitats. Besides this it has shown promising heavy
metals sorbing property because once they contaminate the environment have permanent adverse ecological effects like Cd and it also
can take up and store several trace metals for metabolic and biological process like Hg, Ni, and Zn etc. which are toxic to biota above
threshold levels. In this present study we have undertaken to evaluate the different pharmacological activities with a correlation of
chemical constituents available with this plant so that it may serve as a reference for further studies besides all those above ecological
beneficial activities.
Key words: Hydrilla, Vitamin B12, chemical constituents, Nutritional Values
ABSTRACT:
The acute toxicity tests lasting 96 hours were performed on Clarias gariepinus of mean weight 138 ± 12g and mean total length of 28.0 ±
1.5 cm. The LD50 of lead nitrate was 57.5mg/l. The experiment lasted for 70days after the control and the experimental groups were
exposed to sub-lethal concentrations (20mg/l and 35mg/l) of lead nitrate. Haemoglobin concentrations were significantly (p < 0.05)
decreased to values between 6.64 ± 0.23 g/dl to 5.42 ± 0.58 g/dl in all the sub-lethal concentrations compared to the control values of
8.58 ± 0.48 g/dl. Haematocrit values were similarly significantly (p < 0.05) lowered from the control value of 26.8 ± 0.68 iu/l to 20.8 ± 0.76
iu/l and 17.0 ± 1.67 iu/l for 20mg/l and 35mg/l lead nitrates respectively. The mean values of RBC count were significantly (p < 0.05)
lowered from the control value of 4.38 × 1012 ± 0.26 to between 3.39 × 1012 ± 0.12 and 2.72 × 1012 ± 0.02 in 20mg/l and 35mg/l lead
nitrate respectively. The WBC count significantly (p < 0.05) increased from 20720.00 ± 307.77 in the control to 20940 ± 875.72 and
23620.00 ± 402.01 in the two sub-lethal levels respectively. The serum enzymes of the control 40.00 ± 4.07 iu/l (ALP), 34.8 ± 1.18 iu/l
(ALT) and 119.8 ± 13.24 iu/l (AST) were significantly (p < 0.05) higher than the experimental group at 20mg/l lead nitrate 38.2 ± 4.48 iu/l
(ALP), 33.6 ± 4.43 iu/l(ALT) and 113.4 ± 14.77 iu/l(AST) while the values at 35mg/l lead nitrate were 31.0 ± 5.84 iu/l, 26.2 ± 2.67iu/l and
97.6 ± 14.15 iu/l respectively. There were no significant differences (p < 0.05) in MCHC, MCH and MCV values between the control and
the experimental groups. This study has sufficiently contributed to the basic research needs of aquatic toxicology and fish pathology.
Key words: Clarias gariepinus, toxicological effects, haematological indices, lead nitrate.
ABSTRACT:
Conventional ophthalmic dosage forms have lower bioavailability due to many factors like precorneal loss factor, tear dynamics, low
residence time etc. Another reason for lower bioavailability is lower permeation of conventional dosage form. This research is based on
formulation of liposomal suspension to increase the lipophilic cornea. This liposomal suspension was converted in to hydogel using
carbopol 934 to increase residence time. Ciprofloxacin is broad –spectrum antibiotic effective against many Gram-positive and Gram-
negative bacteria. Distearoylphosphatidylcholine (DSPC) is synthetic lipid which gives more stability to liposome as compare to natural
lipid. The research work started with optimization of processing factors like CH: DSPC ratio, rotating speed, hydration time, drying time,
hydration volume and drying temperature. Liposome characterization was done using scanning electron microscopy (SEM). Diffusion
study was carried out for comparison between liposomal suspension and hydrogel.
Key words: Liposome, Hydrogel, Carbopol 934, DSPC
ABSTRACT:
The present study is aimed to develop extended release tablet of Pregabalin using hot melt granulation method which will include
hydrophobic polymer that will form hydrophobic matrices which will retard release of drug for extended period of time. Different
concentration of Compritol ATO 888 and Hydrogenated Castor Oil were utilized for desired criteria of optimized batch. A 32 full factorial
design was employed for optimizing the concentration of hydrophobic polymer. The tablets were evaluated in terms of average weight,
friability, hardness and in vitro drug release profile. Optimized batch was also evaluated for in vitro drug release profile in presence of
alcohol and short term stability study. The kinetic model fitting of the optimized batch was carried out to find out the mechanism of drug
release from the tablet and Korsmeyer and Peppas model fits best for the release of the drug from the tablet. The n value was
determined using korsmeyer and peppas model and mechanism of drug release was found to be non fickian diffusion. The optimized
batch shows satisfactory results with respect to theoretical drug release profile.
Key words: Extended release tablet, Pregabalin, Compritol ATO 888, Hydrogenated Castor Oil.
ABSTRACT:
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Background: In India, the system of reporting Adverse Drug Reactions (ADRs), Pharmacovigilance (PV), has not progressed well and it's still in infancy stage.
This can be determined by the reporting of only 1% of ADRs as compared to 5% of the other countries of world. The major drawback of the slow progress of PV
system is the lack of sufficient knowledge towards it by healthcare professionals.
Objective: To evaluate the knowledge and practice of ADR reporting by physicians and pharmacists in community settings.
Method: A self-administered questionnaire was prepared. After explaining the intention of survey, it was distributed to pharmacists and doctors (General
practitioners, MDs, and Surgeons), in the community setting. Participants were requested to fill out the questionnaire. Healthcare professionals, who did not
wish to participate in the study, were excluded.
Result: A total of 110 questionnaire were circulated in the two major cities of Gujarat, namely Ahmedabad and Gandhinagar, of which 100 (50 Doctors and 50
Pharmacists) filled questionnaire were returned, producing overall response rate of 90.90%. Our study results revealed total of 88% responders need the
training to report ADR. 54% and 60% doctors and pharmacists respectively, did not know the existence of Pharmacovigilance Program of India (PVPI), and 74%
and 60% doctors and pharmacists respectively, did not know the nearest PV center. Overall 90% responders had never reported suspected ADR before. 91%
responders suggested that regular information should be provided regarding ADR by PVPI. Of all the responders, 76% and 88% doctors and pharmacists
respectively suggested that the trained pharmacist could be the right person to assist physicians in ADR reporting. For the reason of not reporting an ADR, the
highest percentage was noted (58%) with, if the reaction was well recognized for a drug.
Conclusion: Our study has shown that the knowledge and practice of doctors and pharmacists on ADR reporting was unsatisfactory, and that the ADRs are
under-reported. This indicates that there is a strong and immediate need to increase awareness and impart training to healthcare professionals regarding the
importance of ADR reporting and health outcomes.
ABSTRACT:
4-(4-chlorophenoxy)-1,2-dimethylbenzene react with 1-(4-hydroxyphenyl)ethanone in presence of copper metal as a catalyst gives 1-(4-
(4-(3,4-dimethylphenoxy) -phenoxy)phenyl)ethanone ,this derivatives react with various substituted aldehyde to give corresponding
substituted chalcone derivatives .Now these derivatives on condensation with thourea gives the vast rang of Thioxo Tetrahydro
Pyrimidine derivatives. Structure elucidation of synthesized compound had been made on the basis of element analysis, 1H NMR
Spectra studies.
The microbial activity of the synthesized compounds has been studied against the species bacillus subtillis, staphylococcus aureus,
Escherichia coli, and salmonella typhi.
KEY WORDS: Synthesis, heterocyclic substituted chalcone derivatives, Pyrimidine derivatives, Chalcones
