Synthesis and Biological Evaluation of Some Novel Substituted Triazoles
Nirmala Patel, Jinali M. Amin
Self Emulsifying Drug Delivery System of Fenofibrate
Dhaval Patel, Nishith K. Patel
Volume 6, Issue 2
Pages no. 178-212
Available online on 01 March 2016
ISSN 2277-3681
J Pharm Sci Bioscientific Res. 2016; 6(2):178-212
Effect of Tobacco Smoking on Oral Mucosa in Orthodontic Patients - A Cytomorphometric Study
Vinay Marla*, Singh Varun Pratap 
An Empirical Review on Behaviour Consequences of Drug Addict
Sharma Jyoti, Pawar Dilip
Development and Validation of Analytical Methods for Simultaneous Estimation of Rosuvastatin, Clopidogrel and Aspirin in
Pharmaceutical Dosage Form
Rashmi. D. Singh, Hitendra Yadav, Madhuri Hinge, Alisha patel
Development and Validation of Analytical Methods for Estimation of Leucovorin Calcium in Its Marketed Dosage Form
Namrata Patel, Nishith Patel, Bhumika Shakhareliya, Mandev B. Patel
Formulation and Evaluation of Simvastatin SEDDS
Prajapati Paresh A, Maheshwari Mittal M.,
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Formulation and Evaluation of SEDDS containing lipid lowering Drug
Maheshwari Mittal M., Prajapati Paresh A
LC-MS Analysis and Standardization of Khadirarishta - A polyherbal
Sharma Ila
Genotoxic Analysis of Oral Buccal Mucosal Cells in Patients Undergoing Fixed Orthodontic Treatment - A Case
Control Study
Singh Varun Pratap, Vinay Marla
Awareness to Hazards of Addiction and Drug Abuse in Bhopal City
Pawar Dilip, Sharma Jyoti
ABSTRACT:
A series of 3-(methylthio)-5-phenyl-4H-1, 2, 4-triazol-4-substituted amine were synthesized. The synthesized compounds
were characterized through various instrumental techniques viz., FTIR, FT-NMR, and MS. All the compounds were tested
against two different strains of fungi. Compound 7a, 7b, 7c, 7d emerged as most potent molecule against Aspergillus niger.
Compound 7e have shown MFC at 12.5 µg/ml against Candida albicans and all the other compounds have shown MFC
value 50 µg/ml against Candida albicans.
KEY WORDS: Synthesis, Cilostazole, Triazoles, Aspergillus niger, Candida albicans.
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ABSTRACT:
In current study formulation of self emulsifying drug delivery system of Fenofibrate was carried out using Lipd phase,
emulsifier and co emulsifier flax seed oil, tween 20 and polyethylene glycol 600 respectively. various oil, emulsifier and co
emulsifiers were selected based on their solubility. Using water titration method ternary phase diagram ware prepared for
SEDDS and emulsification region were analysed visually. All prepared formulations were evaluated for dilution studies, self
emulsification time, drug content, in-vitro dissolution, droplet size determination, zeta potential measurement, viscosity
determination and thermodynamic stability study. Based on stability study results, viscosity and usage of less emulsifier the
final formulation were prepared. The comparison of invitro dissolution study of final formulation shows 5.4 fold and 1.8 fold
increases in dissolution at 60 min with pure drug and marketed formulation respectively.
KEYWORDS: Atorvastatin calcium, microemulsion based tablet, Liquid retention potential, Career: coat ratio
ABSTRACT: Objectives: To analyse the cytomorphometrical changes in oral buccal mucosal cells of tobacco smokers
undergoing fixed orthodontic treatment. Materials & Methods: Buccal smears were prepared, stained with Papanicolaou's stain
and observed at 400x magnification. Digital images were obtained and analysed with 'Image J' software and data entered. One
way ANOVA & Post Hoc test were performed to test the difference of various parameters among and between groups. Results:
Cell diameter showed a significant reduction (p=0.032) in smokers undergoing orthodontic treatment as compared to normal
individuals. Conclusion: Tobacco smokers undergoing fixed orthodontic treatment did not show any significant cellular and
nuclear changes other than a reduction in cellular diameter.
Key Words: cytomorphometry, exfoliative cytology, fixed orthodontic treatment, oral buccal mucosal cells.
ABSTRACT:
IDrug addiction is a chronic condition characterized by obsessive, or uncontrollable, drug seeking and leading harmful
consequences and changes in the brain, which can lead to crime, guilt or death. Drug addiction is also a relapsing disease and
careful long term treatment required to stop using again after treatment. The path to drug addiction begins with the voluntary act
of taking drugs. But after compromised with person's ability of what to choose and what not, gradually it affects parts of the brain
involved in reward and motivation, learning and memory, and control over behavior. As addiction is a chronic disease, it is not
easy to stop using drugs after developing abuse. Most patients need long-term or repeated care to stop using completely and
recover their lives.
KEYWORDS: Addiction, Drug abuse, Impact of addiction, Treatment for drug addiction, Addiction cycle.
A novel liquid chromatographic-Time of Flight mass spectrometric (LC-TOF-MS) method has been developed for the determination of
Khadirarishta, polyherbal fermented Ayurvedic medicine made out by heart wood of Acacia catechu along with other herbal ingredients. It is
having anti-lipid peroxidation activity with human erythrocytes. Results indicate that khadirarishta has good antioxidant potential and reduces
lipidperoxidation in human erythrocytes. To determine the content, LC-MS study was carried out of herbal formulation.The chromatographic
separation was achieved within 30 min by using Water (0.1% Formic acid): Acetonitrile as mobile phase with gradient system and Agilent
Zorbax C18 column (100 x 2.1 mm, 1.8µm), the flow-rate was 0.3 ml/min. Ion signals m/z between 40 to 1700 was measured in the positive
mode. The method was simple, sensitive, precise, accurate and was successfully applied to the herbal formulation and individual standard
compound.
KEYWORDS: Khadirarishta, Lipid peroxidation, LC-MS, herbal formulation, Anti-oxidant.
ABSTRACT:
A newer, simple, accurate and sensitive Simultaneous Equation method is developed for the simulataneous estimation of
Rosuvastatin (ROS), Clopidogrel (CLOP) and Aspirin (ASP) in pharmaceutical dosage form. Simultaneous Equation method was
developed using three wavelenghts which are 243.56 nm (?max of ROS), 223.38 nm (?max of CLOP) and 276.44 nm (?max of
ASP). In Simultaneous Equation method ROS, CLOP and ASP obeyed Beer's law in the concentration range of 1-5 µg/ml for
ROS, 7.5-37.5 µg/ml for CLOP and 7.5-37.5 µg/ml for ASP. Methanol was used as a solvent. The results of the analysis were
analyzed and validated statistically and recovery studies were carried out as per ICH guidelines. It can be used for routine analysis
of three drugs in bulk as well as in pharmaceutical formulations.
KEY WORDS: Rosuvastatin (ROS), Clopidogrel (CLOP), Aspirin (ASP), Simultaneous Equation Method.
ABSTRACT:
RP-HPLC Method For Estimation of Leucovorin Calcium In A Tablet Formulation. An isocratic reversed phase HPLC method has
been developed for the determination of Leucovorin Calcium on a C18Phenomonex (250 x 4.6 mm) column using a mobile phase
consisting of 0.00 5M tetrabutyl ammonium phosphate buffer pH 6.6 (70:30,v/v) at a flow rate of 1 mL/min and the detection was
carried out at 292 nm. Retention times of Leucovorin Calcium was found to be 3.99 min. The method was validated with respect
to specificity, linearity, accuracy, precision, ruggedness and robustness. This method is simple, precise, and sensitive and is
applicable for simultaneous quantification of Leucovorin Calcium in a tablet formulation
Keywords: isocratic, reverse phase, validation, Leucovorin Calcium, RP-HPLC
ABSTRACT:
The present study was done to formulate the self emulsifying drug delivery system of Lovastatin, a lipophilic drug for improvement in in-
vitro dissolution and thereby oral bioavailability. Final optimized formulation consisted of oil (), surfactant (Cremophore El) and co-
surfactant (Capmul MCM) and solid carrier (Neusilin US2) for adsorption. At first, calibration curve of lovastatin was generated, and then
based on saturation solubility studies in different vehicles; oil, surfactant and co-surfactant were screened. Pseudo ternary phase
diagrams were used to get micro emulsion region, based on which liquid self emulsifying drug delivery systems of lovastatin were
formulated. They were characterized by macroscopic evaluation by visual assessment, self-emulsification time, % Transmittance, globule
size, zeta potential, and thermodynamic stability study. In vitro drug dissolution of optimized liquid self emulsifying formulation showed
that % release of lovastatin found 99.03±0.31within 30 min which was comparable to marketed tablet of lovastatin 72.91±0.5. The
globule size found was 16.1 nm from the optimized Liquid self emulsifying formulation. Optimized liquid self emulsifying formulation was
successfully solidified using carrier Neusilin US2 by adsorption technique. Solid SEDDS was characterized by flow property, particle size,
zeta potential measurement, % Transmittance, % drug content and in-vitro dissolution test and found that there was not much difference
in dissolution behavior of solid and liquid SEDDS. Even it passed stability studies. So it was concluded that lovastatin solid self
emulsifying drug delivery system was successfully developed to improve its rate and extent of dissolution.
KEYWORDS: Lovastatin, BCS class II drug, Self emulsifying drug delivery system, dissolution
ABSTRACT:
The present study was done to formulate the self emulsifying drug delivery system of Simvastatin, a lipophilic drug for improvement in in-
vitro dissolution and thereby oral bioavailability. Final optimized formulation consisted of oil (oleic acid), surfactant (Tween 80) and co-
surfactant (Capmul MCM) and solid carrier (Neusilin US2) for adsorption. At first, calibration curve of simvastatin was generated, and
then based on saturation solubility studies in different vehicles; oil, surfactant and co-surfactant were screened. Pseudo ternary phase
diagrams were used to get micro emulsion region, based on which liquid self emulsifying drug delivery systems of simvastatin were
formulated. They were characterized by macroscopic evaluation by visual assessment, self-emulsification time, % Transmittance, globule
size, zeta potential, and thermodynamic stability study. In vitro drug dissolution of optimized liquid self emulsifying formulation showed
that % release of simvastatin found 99.76±0.21 within 30 min which was comparable to marketed tablet of simvastatin 70.37±0.45. The
globule size found was 14.69 nm from the optimized Liquid self emulsifying formulation. Optimized liquid self emulsifying formulation was
successfully solidified using carrier Neusilin US2 by adsorption technique. Solid SEDDS was characterized by flow property, particle size,
zeta potential measurement, % Transmittance, % drug content and in-vitro dissolution test and found that there was not much difference
in dissolution behavior of solid and liquid SEDDS. Even it passed stability studies. So it was concluded that solid self emulsifying drug
delivery system was successfully developed to improve its rate and extent of dissolution.
KEYWORDS: Simvastatin, BCS class II drug, Self emulsifying drug delivery system, dissolution
ABSTRACT:
Objective: A cross-sectional study was undertaken to analyse the genotoxic effects occurring during fixed orthodontic treatment on the cells of
oral buccal mucosa. Materials & Methods: The study included two groups (n=20 each), one including healthy adult individuals undergoing fixed
orthodontic treatment and the other served as control. Oral buccal mucosal cells were collected as per the principles of exfoliative cytology and
stained using a Rapid PAP kit. Micronuclei count was done using a compound light microscope in 500 non overlapping cells in a step ladder
fashion. Results: Statistical analysis revealed a significant increase in the number of cells showing micronuclei (p<0.001) and the total number
of micronuclei (p<0.001) in patients undergoing fixed orthodontic treatment. Conclusion: Based on these findings it can be suggested that fixed
orthodontic treatment causes genotoxic effects on the oral buccal mucosal cells.
KEYWORDS: exfoliative cytology, fixed orthodontic treatment, micronuclei, oral buccal mucosal cells.
ABSTRACT:
Drug addiction is an obsessive, or uncontrollable, drug seeking chronic relapsing brain disease. Drug abuse causes serious health issues
including HIV. The number of addicts in India increases day by day and the issue need to be take in to consideration. Awareness not only
towards prevent drug and alcohol addiction but also towards de-addiction and re-habitation is required. There are many consequences of
addiction that includes health issue, family problems, social problems, financial and occupational issue and legal issues. All these problems can
be avoided or short out by deaddiction and for that awareness need to spread in society. Government of India is promoting various NGO and
self-finance trusts with funds for implementation of deaddiction and rehabilitation.
KEYWORDS: Drug Addicts in Bhopal, Kind of addiction in Bhopal, Impact of addiction on Bhopal, Awareness to drug addiction
