3-(1-Naphthoyl)Acrylic Acid as Substrate for the Synthesis of Novel Heterocyclic Compounds with Expected
Antimicrobial Activity
Ahmed Sobhy Fawzy*, MA. EL-Hashash, A. Essawy, SA. Rizk, I. E. El-Shamy
A Rapid RP-HPLC Method for Determination of Dihydroartimisinine Derivatives Followed by LC-MS/MS
Characterization to Confirm its Stability during Routine Analysis
Pinak Patel*, Gautam Chauhan, Krunal Detholia
Volume 7, Issue 2
Pages no. 178-224
Available online on 10 April 2017
ISSN 2277-3681
J Pharm Sci Bioscientific Res. 2017; 7(2):178-224
Design and Development of Combination Therapy for Treatment of Multiple Sclerosis
Priyaranjan Pattanaik, Kanu. R. Patel
Preparation and Evaluation of Ziprasidone Fast Dissolving Tablets by Direct Compression Method
Mohammed sajjid, Kishore.V.C, Upendra Kulkarni*
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Chlorthalidone, Cilnidipine and
Irbesartan in their Combined Marketed Dosage Form
Navinraj D Mourya, Yural Prajapati, Bhumika Sakhreliya
Development and Validation of Analytical Method for Simultaneous Estimation of Metformin Hydrochloride and
Teneligliptin Hydrobromide Hydrate in Pharmaceutical Dosage Form
Manish D. Patil, Mayank Bapna, Priyanka Shah , Suleman S. Khoja
Drug Eluting Intraocular Lens
Ravi D. Patel, Margi R. Patel, Bhumika S. Amin
Copyright © 2014 JPSBR Publications
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UV Stabilizers for Novel Acrylate base Intraocular Lens
Pradip S. Patel, Ravi D. Patel, Margi R. Patel
ABSTRACT: This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleophiles under Aza-
Michael reaction conditions to afford the corresponding Aza-Michael adduct 2(a-h)which allowed to react with hydrazine hydrate,
hydroxyl amine hydrochloride and acetic anhydride to form novelpyridazinone3(a-c),oxazinone4(a-c) and furanone5(a-c)
derivatives respectively. Some of the new products showed antimicrobial activities.
KEY WORDS: β–aroylacrylic acids, Aza-Michael, Pyridazinone, Oxazinone, Furanone, 3-(1-naphthoyl)acrylic acid, Antimicrobial
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ABSTRACT: Current research work describes rapid reverse phase high performance chromatographic method for estimation of
dihydroartimisinine derivative namely arteether and artemether from bulk. This method was extended for liquid chromatography-mass
spectrometry analysis to confirm the stability of component under analysis. The mentioned components were separated on HYPERSIL®
ODS C18 column (200 mm× 4.6 mm). The components were eluted by application of Methanol: Acetonitrile (60:40 v/v) as mobile phase
at 216 nm and flow rate of 1 ml/minute. Retention time for artemether and arteether was found to be 1.52 and 2.70 minutes respectively.
For LC-MS/MS characterization mobile phase was spiked with 0.1% ammonium format and ESI was utilized as ionization source in
combination with ion trap as mass analyzer. The components were found to be stable during and after their evaluation period. Method
was found to be linear in concentration range of 10 to 50 µg/ml for both components. The method was further validated as per ICH
guidelines to confirm its suitability for routine analysis.
KEY WORDS: Arteether, Artemether, Reverse phase - High performance Chromatography, Analytical Method validation, Hyphenated
Tandem mass spectroscopy
ABSTRACT: Combination therapies are recent trends used to treat critical diseases based on the synergistic effects. Present study is
designed to develop fixed dose combination of two drugs to treat multiple sclerosis with reduced side effect and more effectively. Fixed dose
combination was designed as capsules in tablets. Capsules are filled with delayed release tablets and immediate release blend that required
for immediate action by achieving blood level immediately and delayed release tablets to add on effect. Teriflunomide and Dimethyl Fumarate
were selected to treat multiple sclerosis in which Teriflunomide was designed for immediate action and Dimethyl Fumarate for delayed action
maintain optimum plasma levels of both drugs at a time and for a prolonged period. Wet granulation process was adopted for immediate
release formulation whereas direct compression process was selected for delayed release layer with optimized excipients concentrations.
Formulation variables for immediate release layer include sodium starch glycolate as super disintegrant and hydroxy propyl cellulose as
binder. Methacrylic acid copolymer is used as delayed release polymer in Dimethyl Fumarate Tablets for delayed action. Physico-chemical
parameters like weight variation, lock length, disintegration time and in-vitro dissolution of capsules were evaluated.
KEY WORDS: Combination therapy, delayed release, multiple sclerosis, Sodium starch glycolate, Methacrylic acid
ABSTRACT:
The aim of this study was to prepare fast disintegrating tablets of Ziprasidone by using various superdisintegrant. The tablets were
prepared using mannitol as diluent and Kyron T-134 as taste masking agent along with three different levels of superdisintegrant.
The superdisintegrant used in this study were Crosspovidone, Crosscarmelose sodium and Sodium starch glycolate. The tablets
were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and
dissolution study. Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar
way. From the results obtained, it can be concluded that the tablet formulation prepared with 9% Crosspovidone showed
Disintegration time of 12 seconds.. Also the hardness, friability, dissolution rate (ZD3) were found to be acceptable according to
standard limits.
KEY WORDS: Ziprasidone, Fast disintegrating tablets (FDT's), Direct Compression, Kyron T-134
ABSTRACT: A Simple, rapid, economical, precise and accurate Reverse Phase Method High Performance Liquid
Chromatography(RP – HPLC) Method For Simultaneous Estimation of Cilnidipine, Chlorthalidone, and Irbesartan in their
combined dosage form has been developed. The RP- HPLC method was developed for the simultaneous estimation of
Cilnidipine, Chlorthalidone, Irbesartan in their combined dosage form development method has been achieved. The separartion
was attained by Column – C18 (25 cm 0.46 cm) Hypersil BDS and Ammonium Acetate buffer 0.05M (pH 3.0): Acetonitrile (60:40
v/v)as mobile phase at a Flow rate 1 ml per minute , Detection was carried out of wavelength of 226 nm retention time of
Cilnidipine, Chlorthalidone, Irbesartan were found to be 6.923 min, 4.097 min, 2.967 min respectively. The method has been
validated for linearity, accuracy and precision. Linearity observed for Cilnidipine 0.5-1.5 µg/ml , for Chlorthalidone 0.625-1.875
µg/ml, for Irbesartan 15-45 µg/ml. The percentage recovery obtained for Cilnidipine, Chlothalidone, Irbesartan were found to be
in range 99.93 ± 0.70 , 99.41±0.82, 99.47 ±1.17 respectively. Developmet method was found to be accurate, precise and rapid
for simultaneous estimation of Cilnidipine, Chlorthalidone and Irbesartan in their combined dosage form.
KEY WORDS: RP – HPLC, Hypersil BDS and Ammonium Acetate buffer, Acetonitrile, Cilnidipine, Chlorthalidone and Irbesartan,
Simultaneous Estimation
ABSTRACT: A reversed-phase liquid chromatographic method has been developed and validated for estimation of Metformin Hydrochloride and
Teneligliptin Hydrobromide Hydrate in Pharmaceutical Dosage Form. RP-HPLC method, Column used was 250 x 4.6mm C18, Hypersil BDS with mobile
phase containing Water (pH 4.0, adjust with 1% Orthophosphoric acid): Methanol (60:40). The flow rate (1.0 ml/min) and wavelength (236 nm). The
retention time was found to Metformin HCl and Teneligliptin HBr Hydrate was found to be 3.317 ± 0.01 min. and 4.783 ± 0.01 min. respectively.
Correlation co-efficient for Metformin HCl and Teneligliptin HBr Hydrate was found to be 0.999. Assay result of marketed formulation was found to be in
99.3 % and 98.3 % for Metformin HCl and Teneligliptin HBr Hydrate. The proposed method was validated with respect to linearity, accuracy, precision and
robustness. Percentage recovery for Metformin HCl and Teneligliptin Hydrobromide Hydrate was found to be 99.0 – 100.0%. Analysis proves that the
developed method was successfully applied for the analysis of pharmaceutical formulations and can be used for routine analysis of drugs in Quality
Control laboratories.
KEYWORDS: Metformin HCl, Teneligliptin HBr Hydrate, HPLC, analytical method development, Validation, ICH, USFDA, Chromatography.
ABSTRACT:
The aim of the current study is to design and characterize sustain antibiotic release intraocular lens (IOL) using a fourth generation fluoroquinolone
antibiotic, Moxifloxacin hydrochloride for availability of antibiotics immediately in postoperative period after cataract surgery. Different novel acrylate
base monomers with the combination of Moxifloxacin hydrochloride formulated for the synthesis of such type of IOL. The prepared IOL were
evaluated for surface quality (MTF value), refractive index, extractable, tensile strength, in vitro drug release studies and microbiological studies. The
selected IOL showed sustained release for the period of 7-week thus showing increased residence and contact time with eye. All studies showed
favorable results thus drug eluting IOL system can be considered as alternative for conventional ophthalmic drops.
KEYWORDS: Intraocular lens (IOL); Fluoroquinolone; Moxifloxacin Hydrochloride; refractive index; Tensile strength; microbiological study.
ABSTRACT:
This research article relates to implantable intraocular lenses (IOLs) that have particular combinations of UV absorbers for providing desirable light
transmission characteristics. Numerous UV absorbers like benzotriazole, benzophenone, triazine, etc are known for their UV stabilization activity.
These combinations of UV light absorbers in to the formulated acrylate monomers which polymerized by photopolymerization process, allow an
ophthalmic device material designer, to provide a wide range of different light transmission cut-off curves and/or characteristics like high refractive
index, low glass transition temperature, tensile strength and good optical quality to the implant device material depending upon the combination of
novel acrylate monomers with relative amounts of UV light absorber that are used.
KEYWORD: Intraocular Lens, UV Absorber, Photopolymerization, refractive index, glass transition temperature (Tg), tensile strength.
