Copyright © 2014 JPSBR Publications
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Volume 7, Issue 3
Pages no. 225-261
Available online on 15 June 2017
ISSN 2277-3681
J Pharm Sci Bioscientific Res. 2017; 7(3):225-261
Synthesis and Antimicrobial Activity of some Phthalazin-1(2H)-One Derivatives
M. A. EL-Hashash, S. A. Rizk*, D.B. Guirguis, L.A.Guirguis , S. M. Khairy
A Review on Evaluation and Development of Supersaturatable Formulation of Poorly Water Soluble Drugs
Ashwini S. Mokashi*, Ganesh Patil, Ramesh Bhusal, Ajay Vyas
The Association of Medication Adherence and Demographics in IHD Patients
Pankti T. Shah* , Swapnil D. Shah, Ruchika P. Sharma, Ishani S. Patel , Mustakim. M. Mansuri, Shrikalp S. Deshpande
Liquisolid Compacts Based Orodispersible Tablets to Enhance Solubility of Atorvastatin using Experimental Design
Raj Shah*, Hardeep Banwait, Sahjesh Rathi, Pragnesh Patni
Use of Technological Aids in Healthcare: The Indian Scenario
Sharma Ruchika P. *, Shah Pankti T., Shah Swapnil D., Patel Ishani S., Mansuri Mustakim M., Deshpande Shrikalp S.
Formulation and Development of Minoxidil Loaded Microspheres for Topical Drug Delivery System Using DoE Approach
Pandey Vivek J*, Hardeep Banwait, Sahjesh Rathi, Pragnesh Patni
ABSTRACT:
Past decade has witnessed the increasing number of poorly water-soluble compounds in contemporary
drug discovery pipelines, the concept of supersaturation as an effective formulation approach for
enhancing bioavailability is gaining momentum. This is intended to design the formulation to yield
significantly high intraluminal concentrations of the drug than the thermodynamic equilibrium solubility
through achieving supersaturation and thus to enhance the intestinal absorption. The major problems
faced by scientists developing supersaturatable formulations include degree of supersaturation and
controlling the rate with the application of polymeric precipitation inhibitor and maintenance of post-
administration supersaturation concentration. Scientific publications associated with characterization of
supersaturatable systems and related preclinical and clinical pharmacokinetics (PK) studies are reviewed
and studied. Precisely, this review will address issues related to assessing the performance of
supersaturatable systems including: various approaches for developing supersaturatable formulations, in
vitro test methods to evaluate supersaturatable formulations, and in vivo PK study cases which have
demonstrated direct relevance between the supersaturation state and the exposure observed in animal
models and human subjects.
KEY WORDS: Bioavailability, poorly water-soluble drugs; supersaturation.
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ABSTRACT:
Background: Low adherence to the medications is a major challenge to reach the therapeutic goal in all the
diseases, especially Ischemic Heart Disease. The demographic characteristics may affect the adherence rate. The
incorporation of counselling aids can also improve the adherence. Material and method: 122 IHD patients were
recruited for the study. Their demographic details were collected. They were randomly divided into: Group1 -
Control, Group2 - Android Application, Group3 – Personal counselling and Group4 - Android Application & Personal
counselling. The questionnaire was filled at the baseline and after two months. A telephonic follow-up of 15 days
followed by monthly visit was also done. The data was analysed statistically. Result and Discussion: Males were
more adherent than females. The adherence level varied irrespective of education level. There was association
between age and non-adherence, while it was poor between education and non-adherence (Confidence interval=
95%, α=5%). A 2x2 contingency - Chi square test was significant between gender and the rate of adherence (male-
female vs. adherence non-adherence). Conclusion: The adherence was positivity associated with the age and gender
but not with education.
KEY WORDS: Ischemic heart disease, adherence, demographics.
ABSTRACT: To obtain an enhanced in-vitro dissolution rate of Atorvastatin by using Liquisolid technique and
Liquisolid tablets were optimized by QbD-DoE approach 32 full factorial design using Design Expert Software. The
liquisolid tablets were formulated by using Polyethylene glycol (PEG- 400), as liquid vehicle, Avicel PH-102 as a
carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant.
The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems
and to calculate amount of carrier material and coating material. All prepared liquisolid batches were subjected to
weight variation, drug content uniformity, hardness, friability test, and disintegration test and dissolution tests.
Liquisolid systems were also tested for DSC, FT-IR. From result of check point analysis of design data, ATLCODT1
shows higher Drug release (97.86%) at less wetting time (54.12 sec.) and disintegrating time (5.17 sec) which
enhancing solubility of Atorvastatin by 4.16 mg/ml. Atorvastatin Liquisolid compacts enhance aqueous solubility
and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be
useful to formulate Orodispersible Tablets using Liquisolid Technique which may give rapid onset of action by rapid
absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.
KEY WORDS: Liquisolid technology, Solubility enhancement, Orodispersible Tablet, Dissolution rate, DoE.
ABSTRACT:
Blooming field of technology does not only provide us endless entertainment and knowledge but can be an
exceptional companion in healthcare. Increasing number of digital devices and technological options makes it even
easier to provide effective healthcare due to popularity of technological devices worldwide. Applications of such
aids can help to cope up with increasing demand of effective healthcare with time and cost saving manner actively
and passively. Worldwide numbers of initiative has been taken to address and introduce such aspects yet Indian
scenario is unknown due to lack of studies addressing such issue and quality implementations in respective field.
This work is conducted to analyze current scenario of technological aids in healthcare in India. Without any doubts
improvement in compliance and adherence is noticed at global and Indian level also. There are evidences of
effective management of chronic conditions by technological aids even though there have been several factors
which needs attention to make the most of technological aspects, current scenario needs era of thorough
improvement and quality research to be up to the mark for being most reliable mean of effective healthcare
management.
KEY WORDS: eHealth, Technology, Digital, Adherence, informatics, Healthcare
ABSTRACT: Many marketed conventional topical dosage forms may absorb quickly drug and hence increase dosing
frequency through skin. Conventional marketed gel proposed to act on outer layers of skin which may release API
an application and produce a very much concentrated layer which may be quickly absorbed. Hence the necessity
subsists to exploit on quantity of period that drug which can present inside epidermis with lessening transdermal
penetration keep on body. Minoxidil is a potent direct-acting peripheral vasodilator that reduce peripheral
resistance and produces a fall in blood pressure having adverse effect like cardiovascular effects associated with
hypotension such as sudden weight gain, rapid heartbeat, faintness or dizziness. The major remarkable side effect
of Minoxidil is unnecessary hair growth in various part of the body known as hirsutism on continue prolong oral
use of it. Minoxidil while applying topically promotes the survival of human dermal papillary cells (DPCs) by
activating both extracellular signals regulated kinase (ERK) & Akt so use topically in human baldness or alopesia.
Minoxidil loaded Microspheres was prepared by using solvent evaporation method and evaluated. Minoxidil
loaded Microspheres based topical drug delivery system to capitalize on the measure of time which presents active
ingredients at least dose, lessen side effects due to localized drug within epidermis by reducing transdermal
penetration that delivering the drug at fungal infection site and give drug release profiles.
KEY WORDS: Minoxidil, Microspheres, DoE, Topical gel
