jpsbr issues

ABSTRACT: Consumption of tobacco has always been a high-risk factor for many of oral and other related cancer in a country like India. Identifying various biomarkers present in an individual who is engaged in the activity of smoking carries the potential to limit the emergence of such diseases from occurring. 2,5-Dimethyl furan (DMF) as a biomarker has found to be of great interest among researchers because of its high specificity to tobacco combustion and sensitivity in detecting tobacco exposure. The current review article comprehensively evaluates multiple studies conducted so far, with a focus on 2,5-DMF, its identification from different /biological samples such as exhaled breath, blood, urine, and environmental tobacco smoke (ETS). It also highlights a critical discussion of various methodological aspects established for identifying the same biomarker in individuals who are engaged in the habit of smoking thus offering the readers to compare various methods for 2,5-DMF detection, also simultaneously offering insights into its potential for early detection and prevention of diseases related with tobacco consumption. KEYWORDS: Tobacco consumption, 2,5-Dimethylfuran, biomarkers, breath, urine, blood, Environment tobacco smoke (ETS), coffee.

ABSTRACT: The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method and simultaneous equation method for determination of Ranolazine and Metformin HCl. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an iso absorptive point and other being the λ-max of one of the two components. Simultaneous equation method uses the λ-max of both the drugs. Metformin HCl was determined at 235nm, Ranolazine was determined at 270nm and Iso absorptive wavelength was obtained at 250nm. Methanol and distilled water (50:50) was used as a solvent. The developed method was validated as per ICH guidelines. The Linearity of the calibration curve for each analyte in the desired concentration range was good (r2 > 0.989) by these methods. The method showed good reproducibility and recovery. The methods were successfully applied to pharmaceutical dosage form because of no interference. KEYWORDS: Ranolazine, Metformin HCL, Methanol, Spectrophotometric, Absorbance Ratio Method, Iso absorptive point, Simultaneous equation method, ICH guidelines.

ABSTRACT: The comprehensive overview gazed at the current state of the art use of curcumin-loaded nanofibers made by electrospinning as an implanted cancer medication delivery system. The powerful anticancer properties of curcumin, a naturally occurring polyphenol, are well known. Still, its quick systemic metabolism, low bioavailability, and poor water solubility make it difficult to translate into clinical practice. A clever way around these obstacles is to use electrospun nanofibers, which provide curcumin with a flexible encapsulation medium and allow for regulated release kinetics. By carefully regulating factors like polymer makeup, fiber structure, and medication loading, electrospun nanofibers show great promise for improving curcumin stability, and solubility, delaying its release, and enabling tailored administration to malignant regions. This study highlights the curcumin loaded nanofiber's potential efficacy and safety profiles in preclinical investigations while thoroughly examining their production methods, physicochemical characteristics, and biological applications. It also addresses the difficulties that lie ahead and potential paths forward in integrating this cutting edge technology into clinical practice and transforming cancer treatment approaches. KEYWORDS: Implantable drug delivery system, Curcumin, Nanofibers, Electrospinning method, and Cancer.

ABSTRACT: Drugs can be administered sublingually instead of orally. The effectiveness of sublingual administration is greater when a quick onset of action is needed. Its excellent bioavailability can be attributed to avoiding hepatic first-pass metabolism. A recent study has shown that polymer nanofibers are being studied more because of their incredible qualities, like high porosity and a high surface area to volume ratio. Geriatric patients often face multiple chronic diseases requiring the use of many drugs. The electrospun nanofiber system offers a promising alternative to conventional oral dosage forms, such as tablets and capsules. This system produces ultrafine fibers that provide faster drug release, improved bioavailability, and lower dosages. It can be administered in various forms, such as patches and films, and has shown higher efficacy and greater patient compliance than oral dosage forms. It is a viable option for the treatment of multiple chronic diseases. Electrospinning technology is a highly efficient and reliable manufacturing technique that has garnered significant attention in recent times. Its simplicity and repeatability make it a desirable option for a range of applications. This method is an efficient and cost-effective way to produce continuous nanofibers with desirable properties. These properties include high porosity, high surface area to volume ratio, high loading capacity, high encapsulation efficiency, transport of various medications, and increased drug solubility. Electrospun polymeric nanofibers have important applications in wound healing and the treatment of various conditions such as diabetes, AIDS, cancer, and migraines, asthma. KEYWORDS: Sublingual, polymer, electrospinning, drug delivery.

ABSTRACT: Topical/Transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofibers fabrication with a great potential for drug delivery. More studies in the field of nanofibers containing drug are divided two categories: first, preparation and characterization of nanofibers containing drug and second, investigation of their therapeutic applications. Drugs used in electro spun nanofibers can be categorized into three main groups, including antibiotics and antimicrobial agents, anti-inflammatory agents and vitamins with therapeutic applications. Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications. The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibility and characteristics. This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends. This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical. KEYWORDS: Drug Delivery, Electrospinning, Nanofiber, Polymeric Scaffold, Topical /transdermal drug delivery applications.