ABSTRACT: Domperidone   and   Ilaprazole   are   drugs   used   in   the   treatment   of   gastro-oesophageal reflux.   They   are   also   given   in   combination.   The   current   work   describes   a   simple   UV spectrophotometric   method   for   estimation   of   these   two   in   combination.   It   is   based on   the   principle   of   Absorbance   correction   for   interference.   The   choice   of   285nm and    320    nm    is    based    on    the    fact    that    Ilaprazole    shows    practically    negligible absorbance   at   320   nm   whereas   both   these   drugs   absorb   significantly   at   285   nm. The    method    is    economical,    fast    and    has    been    checked    for    linearity,    accuracy, precision, LOD, and LOQ. KEY WORDS:  Domperidone, Ilaprazole, Absorbance corrected method, Validation.