jpsbr issues

ABSTRACT: To find out the attitude of staff nurses regarding their legal responsibilities in some selected hospitals of selected district Jabalpur in Madhya Pradesh State, three hundred numbers of subjects (nurses) were evaluated by using the formula of population. Sociodemographic variables, a Knowledge Questionnaire, and an Information Booklet were used as tools for the study. From the study, it was found that in the pretest it was detected that a maximum of 229 [76.3%] had poor knowledge, 58 [19.33%] had average knowledge, whereas 13 [4.3%] had good knowledge. The mean score was 7.9183 and SD was 5.5779. In the post-test it was detected that a maximum of 281 [93.67%] had good knowledge, 15 [5%] had average knowledge, whereas 7 [2.33%] had poor knowledge. The mean score was 24.5314 and SD was 3.71. The improvement in knowledge states that the given intervention was effective. In the pretest, it was detected that a maximum of 229 [76.3%] had poor knowledge, 58 [19.33%] had average knowledge, and 13 [4.3%] had good knowledge. The mean score was 7.9183 and SD was 5.5779. In the post-test it was detected that a maximum of 281 [93.67%] had good knowledge, 15 [5%] had average knowledge, whereas 7 [2.33%] had poor knowledge. The mean score was 24.5314 and SD was 3.71. The improvement in knowledge states that the given intervention was effective. The findings showed that there exists a significant association between the socio-demographic variable Age. Gender, Education, Religion, Type of family, Experience, previous experience, and attended any seminar. Also, the hypothesis test state two-sided, with a 0.05 level of significance showed no significant association between the post-test knowledge scores of staff nurses regarding the legal responsibilities of nurses with selected socio-demographic variables for all socio-demographic variables.. KEY WORDS: legal responsibilities, staff nurses, attitude, Information booklet.

ABSTRACT: Purpose: This study aimed to prepare Dried Ferrous Sulphate pellets as an oral iron supplement. Pellets were prepared by the extrusion- spheronization process. Optimization of the process parameters was done to get the desired micromeritic properties of the pellets.Results: The formulation composition of the T4 batch was found suitable based on the ease of preparation, extrusion time, % product yield, pellet appearance, and average pellet size. This formulation was selected for the screening and optimization of extrusion-spheronization process parameters using 3 level 2 factor factorial design (Design expert 10.0.1). Spheronization speed and time as significant process parameters were optimized at 2000 RPM and 15 minutes (Batch F5) based on the desired values of average pellet size( 617 μm), pellet roundness(0.85), and product (16 - 30 # pellets) yield (90 %) found as response variables. For the F5 batch, an immediate and complete In vitro drug dissolution (98.99± 3.5 % SD (n=3)) was found in 0.1 N HCl at 1 hr.Conclusion: Formulation composition and extrusion- spheronization process parameters significantly affected the pellet size and shape. Spheronization parameters were optimized using experimental design. The developed pellet dosage form is a multi-unit dosage form, it facilitates dosage adjustment as the biggest advantage (Iron doses vary based on the iron deficiency level). This formulation contains only iron salt so other minerals like zinc would not compete with iron absorption. The developed product in this study would be a potential alternative to immediate-release single-unit oral iron supplements. KEY WORDS: Dried Ferrous Sulphate, Extrusion-spheronization, Gelucire 43/01, Iron, Roundness

ABSTRACT: Phytoconstituents, such as ellagic acid and eugenol, exhibit remarkable therapeutic properties, but their limited skin penetration has been a persistent challenge in dermatological applications. This comprehensive review explores the formulation, development, and evaluation of phytosomes as a promising strategy to improve the skin permeation of these bioactive compounds. Phytosomes, phospholipid complexes of phytoconstituents, have gained considerable attention due to their ability to enhance solubility, stability, and bioavailability. This review provides insights into the various methods employed for the preparation of ellagic acid and eugenol-loaded phytosomes, emphasizing recent innovations in formulation techniques. Additionally, it discusses the factors influencing the skin penetration of phytosomal formulations, including particle size, lipid composition, and penetration enhancers. The review critically assesses in vitro and in vivo studies conducted to evaluate the efficacy of phytosomes in enhancing skin permeation, highlighting the potential benefits in the treatment of skin disorders and the development of novel cosmetic products. Furthermore, safety considerations, regulatory aspects, and future perspectives on the commercialization of phytosome-based formulations are addressed. KEYWORDS: Phytosomes, skin penetration, bioavailability, formulation, dermatology, phytoconstituents, permeation enhancers

ABSTRACT: In recent years, the simultaneous administration of antihypertensive drug combinations has gained significant importance in the management of hypertension. This comprehensive review article delves into the recent advances in High-Performance Liquid Chromatography (HPLC) methods developed for the quantitative analysis of antihypertensive drug combinations. This review encompasses a wide range of antihypertensive drug combinations, including Azilsartan medoxomil and Cilnidipine, Efonidipine hydrochloride ethanolate and Telmisartan, and Fimasartan potassium trihydrate and Chlorthalidone. Detailed discussions are provided on the methodology used in the development and validation of HPLC methods for the quantification of these drug combinations. The stability-indicating properties of the HPLC methods are explored, with a focus on forced degradation studies under various stress conditions such as acid hydrolysis, base hydrolysis, oxidative stress, and thermal degradation. Results from these studies are presented, shedding light on the robustness and reliability of the developed methods. Optimized chromatographic conditions, including stationary phases, mobile phases, flow rates, and detection wavelengths, are discussed for each drug combination. These conditions are crucial in achieving accurate and precise quantification of the drugs. Validation parameters, including linearity, repeatability, limits of detection, and limits of quantification, are presented to demonstrate the suitability of the HPLC methods for pharmaceutical analysis. Compliance with international guidelines, such as ICH Q2R1, further emphasizes the reliability of these methods. Additionally, the review highlights the potential of HPLC methods in evaluating the stability of antihypertensive drug combinations under various storage conditions. Recommendations for future research and the exploration of new drug combinations are provided to further advance this critical field. In conclusion, this comprehensive review serves as a valuable resource for researchers and analysts in the field of pharmaceutical sciences. KEYWORDS: Antihypertensive Drugs, Drug Combinations, Stability Studies, Analytical Methods, Chromatographic Techniques, Method Validation

ABSTRACT: The evolution of drug delivery systems has ushered in innovative approaches to enhance patient convenience, compliance, and therapeutic efficacy. Among these, mouth dissolving strips (MDS) have emerged as a remarkable solution, revolutionizing the way medications are administered. This comprehensive review delves into the advancements in the formulation and evaluation of mouth dissolving strips, shedding light on their formulation strategies, characterization techniques, and potential applications. Mouth dissolving strips offer a patient-friendly alternative to traditional dosage forms, catering to individuals who face difficulty swallowing conventional tablets and capsules. The review highlights the pivotal role of formulation development in achieving rapid disintegration, enhanced drug dissolution, and improved bioavailability. Excipient selection, polymer optimization, and integration of novel technologies are explored in depth as key factors influencing MDS performance. The review also delves into recent developments in MDS applications across therapeutic areas, including pain management, allergy treatment, and neurological disorders. These developments underscore the versatility and potential impact of MDS in modern healthcare. Moreover, regulatory considerations and patient preferences are explored, emphasizing the need for stringent quality control, compliance with pharmacopeial standards, and consumer-oriented designs. The integration of patient-centric factors, such as taste-masking and ease of administration, further underscores the significance of MDS as a patient-focused delivery system KEYWORDS: Mouth dissolving strips, Formulation strategies Drug delivery, Evaluation techniques, Rapid disintegration, Bioavailability enhancement, Polymer optimization