ISSN 2277 - 3681
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Impact Factor-2.633
(JIF-2015)
Journal of
Pharmaceutical Science and Bioscientific Research
Volume 10
Issue 1, 2020
Spectrophotometric Determination of Beclomethasone Dipropionate in its Pharmaceutical Dosage Form using
Quality by Design Approach
Anchal Singh*, Madhuri Hinge
Formulation and Evaluation of Self-Microemulsifying Drug Delivery System of Fluvastatin Sodium
Abhijeet S. Kunwarpuriya*, Nilesh M Khutle, Amitkumar J. Raval, Vishakha V. Doke
Recent Advance in Microneddle as a Drug Delivery System
Alpesh D Patel*, Maulik R Mehta, Amirash Acharya
Review on Skin Hyperpigmentation: Etiology, Diagnosis and Treatment
Sohan A. Patel*, Jayant. B. Dave, Timir Y. Mehta
ABSTRACT:
A UV Spectrophotometric method was developed by applying Quality by Design (QbD) approach for the determination of
Beclomethasone Dipropionate its pharmaceutical cream dosage form. Enters the nucleus where it binds to and activates
specific nuclear receptors, resulting in an altered gene expression and inhibition of pro inflammatory cytokine production.
Beclomethasone Dipropionate is used as an skin infection in this research work, three critical method variables which are
solvent, scanning speed and sampling interval were assessed by applying Design of Experiment (DoE) approach and was
also optimized. The method optimization was performed using a factorial design 33. Two wavelengths which are 254 nm and
236.60 nm was selected using water, 0.1 N HCl and Methanol as solvents (later Methanol was selected as final solvent).
Linearity was observed at concentration of 5µg/ml-25µg/ml. The correlation coefficients for Beclomethasone Dipropionate at
both wavelengths are 0.9992 and 0.9991 the results of method validation were in the acceptable range as per ICH
guidelines.
KEY WORDS: Beclomethasone Dipropionate, UV spectrophotometry, Quality by design, Validation, Pharmaceutical
formulation.
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ABSTRACT:
Fluvastatin is an HMG co-A reductase inhibitor. Fluvastatin is BCS class III drug with high aqueous solubility (approximately
300 mg/ml) and low permeability characteristics. It shows low absolute oral bioavailability (approximately 17%) due to
decreased permeability and high first pass extraction. Also, Fluvastatin is found to be unstable at acidic environment of
stomach (pH 1.2). Thus, the aim of the present investigation was to develop a self-microemulsifying drug delivery system
(SMEDDS) to enhance the permeability characteristics of hydrophilic drugs and to protect them from hostile environment of gut.
The solubility of Fluvastatin Sodium in various oils was determined to identify the oil phase of SMEDDS. Various surfactants
and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed
to identify the efficient self-emulsifying region. The SMEDDS formulation was optimized by freeze thaw cycles, robustness to
dilution and droplet size and zeta potential tests. The optimized L-SMEDDS formulation containing Fluvastatin Sodium (10mg),
Capmul MCM C8 EP (100 mg), Cremophor RH 40 (66.66 mg) and Labrafil M 2125 (33.33mg) was further evaluated by in-vitro
and ex-vivo release studies. L-SMEDDS was further converted into T-SMEDDS by “Liquid loading technique”. T-SMEDDS of
Fluvastatin Sodium contained Neusilin®, crosspovidone, magnesium stearate and L- SMEDDS loaded into it. The results from
both L-SMEDDS and T-SMEDDS suggest the potential use of SMEDDS to improve GI instability and intestinal permeability of
BCS Class III drug Fluvastatin Sodium.
KEY WORDS: Fluvastatin Sodium, low intestinal permeability, Gastrointestinal instability, Self-micro emulsifying drug delivery
system, Liquid loading technique.
ABSTRACT:
The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and
transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum layer of the skin, which
serves as a barrier for the molecules and thus only afew molecules are able to reach the site of action. A new form of delivery
system called the microneedles helps to enhance the delivery of the drug through this route and overcoming the various
problems associated with the conventional formulations. The primary principle involves disruption of the skin layer, thus creating
micron size pathways that lead the drug directly to the epidermis or upper dermis region from where the drug can directly go
into the systemic circulation without facing the barrier. This review describes the various potential and applications of the
microneedles. The various types of microneedles can be fabricated like solid, dissolving, hydrogel, coated and hollow
microneedles. Fabrication method selected depends on the type and material of the microneedle. This system has increased its
application to many fields like oligo nucleotide delivery, vaccine delivery, insulin delivery, and even in cosmetics. In recent years,
many microneedle products are coming into the market. Although a lot of researchneeds to be done to overcome the various
challenges before the microneedles can successfully launch into the market
KEYWORDS: Transdermal Drug delivery, Microneedle, Solid microneedle, Hydrogel micro needle.
ABSTRACT:
Hyperpigmentation is common dermatological condition. Skin color is determined by melanin and other chromophores and is influenced by
physical factors (ultraviolet radiation) and other endocrine, autocrine, and paracrine factors. Being the largest organ of the body, any abnormality
in skin color can have impact on the patients’ psychosocial impairment of life. In Indian population have verities of hyperpigmentation condition on
skin due to multifactorial region; hence, a multipronged approach is needed in such cases. The biggest challenge in such cases is to treat the
hyperpigmentation itself; hence, counseling and general treatment (the use of broad-spectrum sunscreen, the avoidance of sun exposure, etc.)
play crucial role, and an interdisciplinary approach may be required, especially when the hyperpigmentation is due to a systemic cause. A
thorough understanding of the aetiology and management strategies of hyperpigmentation is of importance in caring for those afflicted and also in
the development of new therapies.
KEY WORDS: Transdermal Drug delivery, Microneedle, Solid microneedle, Hydrogel micro needle.
